The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
Identifieur interne : 000942 ( Main/Exploration ); précédent : 000941; suivant : 000943The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
Auteurs : Paolo Barone [Italie] ; Angelo Antonini [Italie] ; Carlo Colosimo [Italie] ; Roberto Marconi [Italie] ; Letterio Morgante [Italie] ; Tania P. Avarello [Italie] ; Eugenio Bottacchi [Italie] ; Antonino Cannas [Italie] ; Gabriella Ceravolo [Italie] ; Roberto Ceravolo [Italie] ; Giulio Cicarelli [Italie] ; Roberto M. Gaglio [Italie] ; Rosa M. Giglia [Italie] ; Francesco Iemolo [Italie] ; Michela Manfredi [Italie] ; Giuseppe Meco [Italie] ; Alessandra Nicoletti [Italie] ; Massimo Pederzoli [Italie] ; Alfredo Petrone [Italie] ; Antonio Pisani [Italie] ; Francesco E. Pontieri [Italie] ; Rocco Quatrale [Italie] ; Silvia Ramat [Italie] ; Rosanna Scala [Italie] ; Giuseppe Volpe [Italie] ; Salvatore Zappulla [Italie] ; Anna Rita Bentivoglio [Italie] ; Fabrizio Stocchi [Italie] ; Giorgio Trianni [Italie] ; Paolo Del Dotto [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
English descriptors
Abstract
We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22643
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease</title><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name></author><author><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name></author><author><name sortKey="Avarello, Tania P" sort="Avarello, Tania P" uniqKey="Avarello T" first="Tania P." last="Avarello">Tania P. Avarello</name></author><author><name sortKey="Bottacchi, Eugenio" sort="Bottacchi, Eugenio" uniqKey="Bottacchi E" first="Eugenio" last="Bottacchi">Eugenio Bottacchi</name></author><author><name sortKey="Cannas, Antonino" sort="Cannas, Antonino" uniqKey="Cannas A" first="Antonino" last="Cannas">Antonino Cannas</name></author><author><name sortKey="Ceravolo, Gabriella" sort="Ceravolo, Gabriella" uniqKey="Ceravolo G" first="Gabriella" last="Ceravolo">Gabriella Ceravolo</name></author><author><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name></author><author><name sortKey="Cicarelli, Giulio" sort="Cicarelli, Giulio" uniqKey="Cicarelli G" first="Giulio" last="Cicarelli">Giulio Cicarelli</name></author><author><name sortKey="Gaglio, Roberto M" sort="Gaglio, Roberto M" uniqKey="Gaglio R" first="Roberto M." last="Gaglio">Roberto M. Gaglio</name></author><author><name sortKey="Giglia, Rosa M" sort="Giglia, Rosa M" uniqKey="Giglia R" first="Rosa M." last="Giglia">Rosa M. Giglia</name></author><author><name sortKey="Iemolo, Francesco" sort="Iemolo, Francesco" uniqKey="Iemolo F" first="Francesco" last="Iemolo">Francesco Iemolo</name></author><author><name sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name></author><author><name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name></author><author><name sortKey="Pederzoli, Massimo" sort="Pederzoli, Massimo" uniqKey="Pederzoli M" first="Massimo" last="Pederzoli">Massimo Pederzoli</name></author><author><name sortKey="Petrone, Alfredo" sort="Petrone, Alfredo" uniqKey="Petrone A" first="Alfredo" last="Petrone">Alfredo Petrone</name></author><author><name sortKey="Pisani, Antonio" sort="Pisani, Antonio" uniqKey="Pisani A" first="Antonio" last="Pisani">Antonio Pisani</name></author><author><name sortKey="Pontieri, Francesco E" sort="Pontieri, Francesco E" uniqKey="Pontieri F" first="Francesco E." last="Pontieri">Francesco E. Pontieri</name></author><author><name sortKey="Quatrale, Rocco" sort="Quatrale, Rocco" uniqKey="Quatrale R" first="Rocco" last="Quatrale">Rocco Quatrale</name></author><author><name sortKey="Ramat, Silvia" sort="Ramat, Silvia" uniqKey="Ramat S" first="Silvia" last="Ramat">Silvia Ramat</name></author><author><name sortKey="Scala, Rosanna" sort="Scala, Rosanna" uniqKey="Scala R" first="Rosanna" last="Scala">Rosanna Scala</name></author><author><name sortKey="Volpe, Giuseppe" sort="Volpe, Giuseppe" uniqKey="Volpe G" first="Giuseppe" last="Volpe">Giuseppe Volpe</name></author><author><name sortKey="Zappulla, Salvatore" sort="Zappulla, Salvatore" uniqKey="Zappulla S" first="Salvatore" last="Zappulla">Salvatore Zappulla</name></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name></author><author><name sortKey="Trianni, Giorgio" sort="Trianni, Giorgio" uniqKey="Trianni G" first="Giorgio" last="Trianni">Giorgio Trianni</name></author><author><name sortKey="Dotto, Paolo Del" sort="Dotto, Paolo Del" uniqKey="Dotto P" first="Paolo Del" last="Dotto">Paolo Del Dotto</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C2707E76FBB6EAF18B68003488BBC42442387A40</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22643</idno><idno type="url">https://api.istex.fr/document/C2707E76FBB6EAF18B68003488BBC42442387A40/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000542</idno><idno type="wicri:Area/Main/Curation">000470</idno><idno type="wicri:Area/Main/Exploration">000942</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease</title><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Università Federico II and IDC‐Hermitage‐Capodimonte, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><affiliation wicri:level="4"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><orgName type="university">Université de Rome « La Sapienza »</orgName></affiliation></author><author><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia, Ospedale della Misericordia, Grosseto</wicri:regionArea><wicri:noRegion>Grosseto</wicri:noRegion></affiliation></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche Università di Messina</wicri:regionArea><wicri:noRegion>Scienze Psichiatriche ed Anestesiologiche Università di Messina</wicri:noRegion></affiliation></author><author><name sortKey="Avarello, Tania P" sort="Avarello, Tania P" uniqKey="Avarello T" first="Tania P." last="Avarello">Tania P. Avarello</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia, Ospedale Villa Sofia CTO, Palermo</wicri:regionArea><wicri:noRegion>Palermo</wicri:noRegion></affiliation></author><author><name sortKey="Bottacchi, Eugenio" sort="Bottacchi, Eugenio" uniqKey="Bottacchi E" first="Eugenio" last="Bottacchi">Eugenio Bottacchi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>U.O. di Neurologia, Ospedale Regionale, Aosta</wicri:regionArea><wicri:noRegion>Aosta</wicri:noRegion></affiliation></author><author><name sortKey="Cannas, Antonino" sort="Cannas, Antonino" uniqKey="Cannas A" first="Antonino" last="Cannas">Antonino Cannas</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Policlinico Universitario, Monserrato, Cagliari</wicri:regionArea><wicri:noRegion>Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Ceravolo, Gabriella" sort="Ceravolo, Gabriella" uniqKey="Ceravolo G" first="Gabriella" last="Ceravolo">Gabriella Ceravolo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica di Neuroriabilitazione, Ospedale Umberto I, Ancona</wicri:regionArea><wicri:noRegion>Ancona</wicri:noRegion></affiliation></author><author><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia, Ospedale Santa Chiara, Pisa</wicri:regionArea><wicri:noRegion>Pisa</wicri:noRegion></affiliation></author><author><name sortKey="Cicarelli, Giulio" sort="Cicarelli, Giulio" uniqKey="Cicarelli G" first="Giulio" last="Cicarelli">Giulio Cicarelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia e Stroke, A.O.R.N. San Giuseppe Moscati, Avellino</wicri:regionArea><wicri:noRegion>Avellino</wicri:noRegion></affiliation></author><author><name sortKey="Gaglio, Roberto M" sort="Gaglio, Roberto M" uniqKey="Gaglio R" first="Roberto M." last="Gaglio">Roberto M. Gaglio</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>U.O. di Neurologia, Azienda Ospedaliera S.Giovanni di Dio, Agrigento</wicri:regionArea><wicri:noRegion>Agrigento</wicri:noRegion></affiliation></author><author><name sortKey="Giglia, Rosa M" sort="Giglia, Rosa M" uniqKey="Giglia R" first="Rosa M." last="Giglia">Rosa M. Giglia</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia, Azienda Ospedaliera S. Elia, Caltanissetta</wicri:regionArea><wicri:noRegion>Caltanissetta</wicri:noRegion></affiliation></author><author><name sortKey="Iemolo, Francesco" sort="Iemolo, Francesco" uniqKey="Iemolo F" first="Francesco" last="Iemolo">Francesco Iemolo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>U.O. di Neurologia, Ospedale Guzzardi, Vittoria, Ragusa</wicri:regionArea><wicri:noRegion>Ragusa</wicri:noRegion></affiliation></author><author><name sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione Salvatore Maugeri IRCCS, Castel Goffredo, Mantova</wicri:regionArea><wicri:noRegion>Mantova</wicri:noRegion></affiliation></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><affiliation wicri:level="4"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento Scienze Neurologiche, Università La Sapienza, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><orgName type="university">Université de Rome « La Sapienza »</orgName></affiliation></author><author><name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica I, Policlinico Universitario, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Pederzoli, Massimo" sort="Pederzoli, Massimo" uniqKey="Pederzoli M" first="Massimo" last="Pederzoli">Massimo Pederzoli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia, Ospedale Civile, Vimercate, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Petrone, Alfredo" sort="Petrone, Alfredo" uniqKey="Petrone A" first="Alfredo" last="Petrone">Alfredo Petrone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia, Presidio Ospedaliero Annunziata, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Pisani, Antonio" sort="Pisani, Antonio" uniqKey="Pisani A" first="Antonio" last="Pisani">Antonio Pisani</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Policlinico Tor Vergata, Fondazione Santa Lucia, IRCCS, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Pontieri, Francesco E" sort="Pontieri, Francesco E" uniqKey="Pontieri F" first="Francesco E." last="Pontieri">Francesco E. Pontieri</name><affiliation wicri:level="4"><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale Sant'Andrea, Universitá La Sapienza, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><orgName type="university">Université de Rome « La Sapienza »</orgName></affiliation></author><author><name sortKey="Quatrale, Rocco" sort="Quatrale, Rocco" uniqKey="Quatrale R" first="Rocco" last="Quatrale">Rocco Quatrale</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia Dipartimento Neuroscienze applicate alla clinica, Ospedale Sant'Anna, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Ramat, Silvia" sort="Ramat, Silvia" uniqKey="Ramat S" first="Silvia" last="Ramat">Silvia Ramat</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Azienda Ospedaliera Universitaria, Firenze</wicri:regionArea><wicri:noRegion>Firenze</wicri:noRegion></affiliation></author><author><name sortKey="Scala, Rosanna" sort="Scala, Rosanna" uniqKey="Scala R" first="Rosanna" last="Scala">Rosanna Scala</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia, Ospedale S. Maria Loreto Nuovo, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Volpe, Giuseppe" sort="Volpe, Giuseppe" uniqKey="Volpe G" first="Giuseppe" last="Volpe">Giuseppe Volpe</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurofisiopatologia Dipartimento Neuro Orto Traumatologia, Presidio Ospedaliero S. Luca, Vallo della Lucania, Salerno</wicri:regionArea><wicri:noRegion>Salerno</wicri:noRegion></affiliation></author><author><name sortKey="Zappulla, Salvatore" sort="Zappulla, Salvatore" uniqKey="Zappulla S" first="Salvatore" last="Zappulla">Salvatore Zappulla</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia, Ospedale Umberto I, Enna</wicri:regionArea><wicri:noRegion>Enna</wicri:noRegion></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica, Universitá Cattolica del Sacro Cuore, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS San Raffaele, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Trianni, Giorgio" sort="Trianni, Giorgio" uniqKey="Trianni G" first="Giorgio" last="Trianni">Giorgio Trianni</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurologia, P.O.F. Ferrari, Casarano, Lecce</wicri:regionArea><wicri:noRegion>Lecce</wicri:noRegion></affiliation></author><author><name sortKey="Dotto, Paolo Del" sort="Dotto, Paolo Del" uniqKey="Dotto P" first="Paolo Del" last="Dotto">Paolo Del Dotto</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>U.O. di Neurologia, Ospedale Versilia, Camaiore</wicri:regionArea><wicri:noRegion>Camaiore</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-08-15">2009-08-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1641">1641</biblScope><biblScope unit="page" to="1649">1649</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C2707E76FBB6EAF18B68003488BBC42442387A40</idno><idno type="DOI">10.1002/mds.22643</idno><idno type="ArticleID">MDS22643</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognition</term><term>nonmotor symptoms</term><term>psychiatric symptoms</term><term>quality of life</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0–32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ‐39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement><orgName><li>Université de Rome « La Sapienza »</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></noRegion><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><name sortKey="Avarello, Tania P" sort="Avarello, Tania P" uniqKey="Avarello T" first="Tania P." last="Avarello">Tania P. Avarello</name><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><name sortKey="Bottacchi, Eugenio" sort="Bottacchi, Eugenio" uniqKey="Bottacchi E" first="Eugenio" last="Bottacchi">Eugenio Bottacchi</name><name sortKey="Cannas, Antonino" sort="Cannas, Antonino" uniqKey="Cannas A" first="Antonino" last="Cannas">Antonino Cannas</name><name sortKey="Ceravolo, Gabriella" sort="Ceravolo, Gabriella" uniqKey="Ceravolo G" first="Gabriella" last="Ceravolo">Gabriella Ceravolo</name><name sortKey="Ceravolo, Roberto" sort="Ceravolo, Roberto" uniqKey="Ceravolo R" first="Roberto" last="Ceravolo">Roberto Ceravolo</name><name sortKey="Cicarelli, Giulio" sort="Cicarelli, Giulio" uniqKey="Cicarelli G" first="Giulio" last="Cicarelli">Giulio Cicarelli</name><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><name sortKey="Dotto, Paolo Del" sort="Dotto, Paolo Del" uniqKey="Dotto P" first="Paolo Del" last="Dotto">Paolo Del Dotto</name><name sortKey="Gaglio, Roberto M" sort="Gaglio, Roberto M" uniqKey="Gaglio R" first="Roberto M." last="Gaglio">Roberto M. Gaglio</name><name sortKey="Giglia, Rosa M" sort="Giglia, Rosa M" uniqKey="Giglia R" first="Rosa M." last="Giglia">Rosa M. Giglia</name><name sortKey="Iemolo, Francesco" sort="Iemolo, Francesco" uniqKey="Iemolo F" first="Francesco" last="Iemolo">Francesco Iemolo</name><name sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name><name sortKey="Pederzoli, Massimo" sort="Pederzoli, Massimo" uniqKey="Pederzoli M" first="Massimo" last="Pederzoli">Massimo Pederzoli</name><name sortKey="Petrone, Alfredo" sort="Petrone, Alfredo" uniqKey="Petrone A" first="Alfredo" last="Petrone">Alfredo Petrone</name><name sortKey="Pisani, Antonio" sort="Pisani, Antonio" uniqKey="Pisani A" first="Antonio" last="Pisani">Antonio Pisani</name><name sortKey="Pontieri, Francesco E" sort="Pontieri, Francesco E" uniqKey="Pontieri F" first="Francesco E." last="Pontieri">Francesco E. Pontieri</name><name sortKey="Quatrale, Rocco" sort="Quatrale, Rocco" uniqKey="Quatrale R" first="Rocco" last="Quatrale">Rocco Quatrale</name><name sortKey="Ramat, Silvia" sort="Ramat, Silvia" uniqKey="Ramat S" first="Silvia" last="Ramat">Silvia Ramat</name><name sortKey="Scala, Rosanna" sort="Scala, Rosanna" uniqKey="Scala R" first="Rosanna" last="Scala">Rosanna Scala</name><name sortKey="Stocchi, Fabrizio" sort="Stocchi, Fabrizio" uniqKey="Stocchi F" first="Fabrizio" last="Stocchi">Fabrizio Stocchi</name><name sortKey="Trianni, Giorgio" sort="Trianni, Giorgio" uniqKey="Trianni G" first="Giorgio" last="Trianni">Giorgio Trianni</name><name sortKey="Volpe, Giuseppe" sort="Volpe, Giuseppe" uniqKey="Volpe G" first="Giuseppe" last="Volpe">Giuseppe Volpe</name><name sortKey="Zappulla, Salvatore" sort="Zappulla, Salvatore" uniqKey="Zappulla S" first="Salvatore" last="Zappulla">Salvatore Zappulla</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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